Huntington’s Disease is a genetic disorder running in families. If a child inherits mutated HTT gene from one parent, they will eventually develop Huntington’s disease at some point in their lives. No current treatment can stop or reverse the progression of the disease and the drugs used to relieve symptoms of side effects ranging from fatigue to agitation.
The best treatment would be one that directly targets the abnormal genes. Interestingly, a cannabis compound may have this ability.
How cannabigerol (CBG) Combat Huntington’s disease
Most cannabis research has been dedicated to tetrahydrocannabinol (THC) and cannabidiol (CBD), but there are dozens of other cannabinoids with unique medical potential as well. cannabigerol (CBG) is one of the least known molecules having a particularly significant potential. All other cannabinoids are from CBG, so it makes sense that cannabinoid some profound medical benefits.
A January 2015 Neurotherapeutics lit study several mechanisms by which GBC can help treat the symptoms associated with Huntington’s disease. The researchers used two different in vivo models of Huntington’s disease more generally identify the benefits of CBG.
In the first model, the mice were given 3-nitropropionate , a toxin that causes the symptoms of Huntington’s disease-like. CBG countered a number of effects of the toxin by reducing pro-inflammatory markers and reactive microgliosis (a form of neuro-inflammation). He also restored the antioxidant defenses that were damaged by the 3NP administration ultimately protecting neurons and improve motor function.
In the second model, the researchers used R6 / 2 transgenic mice , which are genetically modified to display the characteristics of Huntington’s disease, to examine the effects of CBG. The improvement of motor function was not as strong as the mouse 3-NP-drunk, but it was still important.
The most interesting, CBG has had a significant effect on at least seven genes linked to Huntington’s disease. The cannabinoid was able to partially normalize gene expression, all of which were impaired in the R6 / 2 mouse. In addition, it reduces the accumulation of the mutant Huntington protein, which may be responsible for the majority of the symptoms of Huntington’s disease.
cannabigerol (CBG) is also improved neurotrophic growth factor expression of brain-derived factor-1, and peroxisome proliferator-activated receptor-gamma-like growth insulin, which can also confer therapeutic benefits. Indeed, a study 2012 found an attenuated CBG composed as neuroinflammation at least partially by a PPAR-gamma related mechanism.
How cannabinoids can benefit from Huntington’s disease
Several physiological problems associated with HD can be treated with phytocannabinoids. Like many neurodegenerative diseases, excitotoxicity (overstimulation of neurons) and oxidative stress (an imbalance of oxidants and antioxidants) will probably contribute to cell death seen in Huntington’s disease.
A 2013 study with animals have shown that CBD can reduce excitoxicity act as an antioxidant, and modulate inflammation through its neuroprotective effects. Moreover, a study 2012 Review asked that cannabinoids can benefit from Huntington’s disease with anti-inflammatory, neuroprotective and neuroregenerative properties.
Although no clinical trials have been performed, cannabinoids almost certainly have a place in the future treatment of Huntington’s disease.